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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd4348146bb17e96eb5de50011250fb60ba8b75dbeb9c9525b6343cc9c4417c6d' 
  AND token = 'NAexJgcg2szyHPSA2X+GPl9IrNhU5rkRJzZ10Yu4Ib8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}