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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '33169df7e1c4c36b9b1dc30970aeac21af64a925d24d5595eb166022109460a4' 
  AND token = 'StuCfCAPx3xuvfoOcJ/1CrpVhrJY1Tcgi/US38ar0L0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}