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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af5dc695aec14709ec7a9fbfa5291d40521225d5e30354346245ecd210cc1c38' 
  AND token = 'XCsnHBRRQ+EY7socCC3S52XTw7s2KNT6+Vzfu47UGxI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}