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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4c2081b4a358037b809e3f679cadb531a81e29199d09df916a6d1e85fece5a07' 
  AND token = 'CXei+GKBjT++slB9jp7bdmpYbQ2BuHQglzk3fE8gNFQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}