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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4676444ae65f6bfef6e06acc1520dc090c48348c433c7b6150f4e97abc15e3ae' 
  AND token = '5eGGQSgb+yKHx9kTKWH9f0El8SAtxlMkeV/hC/U8ZrI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}