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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '722172a9ef3fe3eb2b9e3dc144e42f7d71db794d4182aea6aad5670b64a7e68a' 
  AND token = 'fdEpWDDsF1kSYxjqwjuR1cPmTxM7PC0+o2Z/hN18YYU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}