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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e721983af8032c9f461dac8b865a451c0c3cd177613b4a2a1f75a3afb14c9bf' 
  AND token = '+5Zt4Hgudkxcr5oO7cjO4nvEdUMbw5zT666wq9G3BJc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}