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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'df0ff3a46d1831ec4b1267c8040f911d296eff92b9ccb9d0729a4bf7879df1e4' 
  AND token = '5xzPbewEckpdAjvgEtIO+M0OOH1bnCG+w3ywtVYR2aA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}