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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16a7a371a2348a99b8478f265bcd729ba0c76a392779b35daf626b32cd742734' 
  AND token = '+JSv0g+0d1c/qtq+cfAb2erZ4cVMH4Lh5lvbPXYQHio=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}