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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10a9cc46a3abbaeeadf1276d4bd8af1035bb52af50fbc1f0621902455b7a2749' 
  AND token = 'TsXTP0n22dw6Dha6KEjWdlnZMj1dEnupZPZ2G26XLSI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}