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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72270498437a4392e08750b0de9768cf11921e23e5567d968808df10e8546331' 
  AND token = '0IpEt+UDHRmUC5TbQLxmB0uG93x6hpB//wOjDMaZURc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}