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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a22b8b50de2f6768d5d04a617c23afee7aa4d07266d291ba7c0f43fc3832a3a2' 
  AND token = '3+W6+HcegcUpXcHCdSmnQAHi6kDXgt4n46Dt1cSe3Jk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}