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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f8c252bc3111feff4c92b9d0f1d3cfcd7ffb5dfc16b63569dff82b9f3d9c2059' 
  AND token = '8IlHqdxW+Vc6u1WUFRYs+HDGW1XkcRaeJNv8pCvN+as=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}