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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2f451050321584241ba863e4689d847b02148c68b28f4f18321fdf310bc20ec4' 
  AND token = 'z16+9ZYRo2aKVHAW17pSSYzpzXMjPS/hZ/Y6VXTf6oM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}