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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '421ba9c59b34b34fbc2ec32542c1d80761f0a0f6ce6abe7429af34da6d8f1aa9' 
  AND token = 'krx037t32b5fUi/6p8g3PczjFMrbgyJ4UkOeySzIsdE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}