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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '280ed0cdfddbf9a04d65dd38d0ff87b17075b6370c363c29da5ccde042bcea48' 
  AND token = '/9IVpfiEfHS4apZh252vNV34vo/lkCibcYEdpP2b4M0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}