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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e397ebfc8675811bde37512be229dd64680f44ab85c1d2f324f43c1cb105151' 
  AND token = 'x81rTd/Ni/Y7RmtZ2qPtjEyOwyKPjRmne6dGGy/qa/4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}