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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '74cfa3ea9eb98909e7703de7af1a88e6ba34b891e60497c22abb0c443e461b1b' 
  AND token = 'REv2GbAkxf+4wW0a5Z/ak4FNRhuD6gYhzX2qE4iyc0o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}