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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1cf50dc212a67d2951c1a01a581d9c52c1f03de5c56f9cc7ac5e5101d600f6a6' 
  AND token = 'LVE5cewXWzCWkLDV39TZqIQQXawNzPxwldGvmNeBRuI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}