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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '74cc143264b4dc922e44aaa65be54ab57cfb9e218c3d8334cc4fda08f9372baa' 
  AND token = 'P8rblAswiDY6vTu/IMuEzYF1FuBvRcXGQeX5TlwPFQg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}