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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '105a81e42356f47b7771b18a91b18aa1b660f0af7c72005df5a0843940d2cea1' 
  AND token = 'PbSK1MgO9n3umFY8DDZltIMtq1Rq4nJNe8GOAyipQ5Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}