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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65d909f9011c709a002d15991a7bbd7dfb4c8067602217b1afa2193a699df548' 
  AND token = 'oTLTRwIRhTkjLq7k81Pz124WG5GOpQ/zIxnRPbz7EbU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}