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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c8c33b6defc299930ef265a2bc22dca0beeef7d8808221de6d17cd038e2696d7' 
  AND token = 'Uy5TtBTGmFvp0a5cWBJUz1JTZkDsxWdPiQC0mEQjSC0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}