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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6c21b56ef0bb77bcc5871805fda63961692e9b03f521121326f857c92fda2565' 
  AND token = 'EYSwB0KzsxW2ZXQwasYtjBV6B0tR7Af+X3Cz/46xRQ8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}