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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '146701e0750ba75e16a4fee57a50a9a13a262452a30992f1bc97c8ab249bf2e6' 
  AND token = '5Up69rCsaSMK0tE9yJWOVtw7+aZvJqMDjDSX06oz6Dk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}