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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4280d61f6fdbcdbbc8c1f9165fb7cf26606112b162bed78b81c3da0ec4e635f2' 
  AND token = '7u2+pldyikBVRCLI7d5GPouIYpOv4BtYP3h7aDWXfoY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}