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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '005946d933bad555e1d66e81b50a4dd4ef9e1d5144d91c201404e257d021976d' 
  AND token = '3OG4EWBgOXcjp4cjcC5+/hc79mny/A1mxSFtpNJjeds=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}