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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ff1c17182758c6b17cd8b61395714a0cfce4f31d2d627c1097bc5dcbb91cc582' 
  AND token = 'YW0ijASVjj4/QhCQqHbo2hHdBWdk+ww61ehDC9DhDBU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}