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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4c4d6879f874240e6a03dbb02a79505ed6d789747a3591284b2be00d55e2d19a' 
  AND token = 'QdrI+HgviV7jAD+TIhYqN46aGG9lL1fkm2I2a3Mq0h0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}