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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1180d3c35bc2ec72402b1cb194daa7715d904d570d7e6d58db1a0d2130430d1c' 
  AND token = 'tC9NSwf+wCcdbIXiRsIbFTXG3mmN6due8r+YdIx4Gqw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}