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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '721aef69cde1e93c0c1c59bb5a6a583ba118a2240ef14eae7e4a6116fde7efde' 
  AND token = 'V1UQxuI5MhP04G4Wd4zR36V9LFAQoSRpmTemQCIg2C0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}