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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e721c0390338448b00f31376f574152107b45a25744ae9751d2e7884e9875c90' 
  AND token = 'Iq+HpNHaL/sWbGa750lqE4NHYW3aEE53N7wxu500tEU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}