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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8d0e45e6de2358d6603e7d20868486f5cb897b58ca0b094b7a08d2de3447a0c7' 
  AND token = 'j9UC0+0jqUdj6J3KOx4cZXx10TkBe/vCuQyOcb/Pxgg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}