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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18550a9d0eca10958a2b02b4d31405ee58fcc82b525aaeb28e0452ef94bc6f9d' 
  AND token = 'hNxaBGO/KcH+RIO0aDYAxZNEcN5y/gj/VW2IBONvvvE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}