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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3578176af184964d91e272dcbad1c26773f0fbd1abb27b2b291dfcc6cbf72b74' 
  AND token = '+Leo1/CuVhYDyB7n8TE6bUctqwfFi1/bcBiMErTrGeQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}