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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a048e50c938a339c9d21e1c9b787c7c400187cad6e817a6f2b19bed769b0ab1f' 
  AND token = 'VKCXs8Sl918LVzUqTiVb7R22hOQXlHRqb0fbXe2aB7s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}