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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de03975fe6e6d661f9870adfd8c2005dbada7fc5e286e7c5136b56c4be1787be' 
  AND token = 'J0bRO8X0KubXa+OeBlQEdCo8yEXp5Tu/ugAngiX4rq0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}