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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '157643dcf872b51f1c3d736b6fb96d4e9b4839b20dac706d0b1fed246c3eec12' 
  AND token = 'u837afz2Zy9N13iN3U5E/kGQznMjBo/xSjpOx0Ezr7I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}