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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '300ede23ac6e07d77a45814e03582bf659a1c73ace2db608c3e05e2afee56952' 
  AND token = 'Rf1XDSYQ5b3VlxWQ5B8Yh8Iw/nhrw9BhGCV8tamFrlE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}