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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '86e8ff36d1eac5da6019b675f7668853e5e19e504ce5081120be52f1f40cbf7f' 
  AND token = 'ST1MIRpvTLDEIlUvBGUHk0a/owoTo1ZQ+QP5RQo9AiY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}