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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25e2c50989d24671010df99ae37005db03298278a7e336f80e5773147e2bef1f' 
  AND token = 'Tjikc01J6bbbg0KCY4zkAeGaXAA2MTUybQJnLy5hC8w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}