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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a521dc84265bde8e00d659f74ed421bf3772cd3cd5d13f9607e5fca867cc9f0a' 
  AND token = 'U3hX19MRKPsqafPVsIB+sAjgEb2j7vtxOjLKqyf2caY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}