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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e342c030bac9f64d1fe8018d9804bea420b2516da815028b37c71445eddc461' 
  AND token = 'oL6XP1Gn3M2UBaO6c0UYTozIbYk+JumWUbMXh8jSr5g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}