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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3ad82822283c2491e3d8fb5215c9fa16640a6b13024339cf6561322cd004c5ec' 
  AND token = 'pU2E2UFrCzvBy7vdeWdu+vh26DTSBsPdD1Z2NJcY3As=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}