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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2148c71d29b387a4602199d5bf685747162a66c4f433c179eebb42baddc336f1' 
  AND token = 'v7RWcZiD5t6YVs2DErdAEgyMVtmDCGNTmEcu2Oitkpc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}