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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3818396ddf3c3d503a8e988f99c66bd16cd8ce6f09beee7fdce2cfdc74e35906' 
  AND token = '3zCjKOjxtdLTAPS+RTZh6V58wn2kArFRj63wt237gww=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}