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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '51d25b6a60ac00fa5cdf0c1687c2ac491e0b63aec91c9fc4c7e42fd7b9b0f6bf' 
  AND token = 'nqpd46pyGxaAop/pYm9WPvrDWlJcJwpwVPMfRSS2GbY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}