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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '270acddfae4e7eeca7e431cf8f8a22e7e7c629b675ec63faaedd814e0244fd6b' 
  AND token = 'TxrpSTJGhEiyWx9cN2kBny+qcDzgWjlKyJ+nHpId5lU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}