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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '642651cc51df7365cd1a04549929da198ef36e55c4547ba0a2e842b3a88c8ec4' 
  AND token = '9fA49nfR0oKAAAH14PCSY/qJkbeixl2zja5lNjPrF/g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}