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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7271ec99c430e0612f83404e5586827be3ef179ddc051306f11c05d9c4a0284b' 
  AND token = 'juGKpx1Fn0CJT3ZGlENa83CXXcaOSjMA/2IT3TqXSqI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}